VPX Meltdown Review

VPX Meltdown Fat Burner Reviews

If you've considered using VPX Meltdown fat burner, you've no doubt opened your eyes wide when you read their sales pitch that Meltdown "combines the Fat loss power of 40,000 chocolate bars without all of the bad side effects." There are many research studies showing the various health and weight loss benefits of dark chocolate, but really, 40,000 chocolate bars? Where do they get a number like that from? In any case, it's simply a marketing tactic.

That aside, looking at VPX Meltdown, it certainly looks like it has potential to be a potent fat burner from several angles: user reviews (anecdotal evidence), active ingredient makeup, and also from real scientific research backing up this diet pill. In an industry where supplement companies make claims without substantiating evidence, it's certainly a breath of fresh air when a supplement maker like VPX backs up their product claims with Actual scientific studies that were published and peer reviewed. We'll get to that in a sec, but first, let's take a look at what's in the VPX Meltdown diet pill.

VPX Meltdown Ingredients

Below is a list of VPX Meltdown diet pill ingredients:

Serving Size 3 Capsules
Servings Per Container 40
Fat Catabolizor & β-3 Potentiator 317mg
Caffeine Anhydrous
M_TTA (Methyl Tetradecylthioacetic Acid)
Yerba Mate Extract
lipolytic Trigger™
3'-5'-CAMP (3'-5'-Cyclic Adenosine Monophosphate)
Super Synephrine™ β-3 Activator™ 20mg
Methyl-Synephrine HCL
Iphoric® Potent Methyl β-3 PEA Matrix 138mg
R-Beta Methoxyphenylethylamine
N-Methyl-Beta-Phenylethylamine
NorEpiphex™ α2-Andrenergic Blockade Complex 9mg
11-Hydroxy Yohimbine
Yohimbine HCL
Alpha-Yohimbine
NorEpiphex™ M-MAOxidizor-I™ 20mg
Methyl-Hordenine HCL

Looking at the ingredient makeup of Meltdown, there are 6 key components, which are the Fat Catabolizor & β-3 Potentiator (317mg), Lipolytic Trigger, Super Synephrine β-3 Activator (20mg), Iphoric Potent Methyl β-PEA Matrix (138mg), NorEpiphex α2-Andrenergic Blockade Complex (9mg), and NorEpiphex M-MAOxidizor-I (20mg).

The Fat Catabolizor & β-3 Potentiator comprises of Caffeine, Yerba Mate, and M_TTA (Methyl Tetradecylthioacetic Acid). I'm sure most known what caffeine is, and that it is well known for its fat burning effects. It increases mental alertness, boosts energy, increase adrenaline levels, and its also a mild diuretic. Yerba Mate is a herb that contain a gentle form of caffeine, it also supplies vitamins, minerals, and 15 amino acids. Research suggests that yerba mate may aid with sleep irregularities and joint pains. Many people drink yerba mate to boost energy without the side effects of coffee.

Now, the MTTA (Methyl Tetradecylthioacetic Acid) is not something you see often in other fat burners. There are a limited few studies done on MTTA, which is a fatty acid, that have demonstrated its effectiveness in fatty acid metabolism in rats. One study done on MTTA involving rats found that treatment using MTTA resulted in reduction of plasma triglycerides by 40%, reduction of cholesterol by 33% compared to control group. They found that fatty acid oxidation significantly increased. These results lead to the conclusion that using MTTA reduced plasma triglycerides by decreasing the availability of fatty acids by increased fatty acid oxidation. [1] There are a few other studies showing similar results; however, all these studies done so far are only on animals, and not human subjects. Despite the very promising results shown by MTTA, it still remains to be seen how effective it is in human subjects.

Super Synephrine β-3 Activator consists of the Methyl-Synephrine HCL. According to the VPX descriptions, Synephrine was not an effective fat loss agent. So they chemically engineered Methyl Synephrine, which provided almost equal amount of thermogenesis compared to ephedrine, but without the side effects. Whether there's any truth to this, I cannot say, as I could not find any conclusive evidence to back up this claim.

Iphoric Potent Methyl β-PEA Matrix has 2 main ingredients which are R-Beta Methoxyphenylethylamine, and N-Methyl-Beta-Phenylethylamine. Phenylethylamine (PEA) helps increase attention and activity and has been shown to relieve depression in 60% of depressed patients. VPX claims they have added 2 new fat loss compounds which are vR-ß-M-PEA (R-ß-Methylphenylethylamine) and n-Methyl-ß-PEA (n-Methyl-ß-Phenylethylamine), which helps fat loss. Chocolate bars contain Phenylethylamine (PEA), so I can see where their 40,000 chocolate bars claim relates to Meltdown, but I still don't see how that number is of any relevance. Well, okay, I have an idea how they arrived at the 40,000 figure... In their promotional literature, they stated that "PEA... inducing thermogenesis to burn fat while eliciting the mild euphoria of eating a 1000 chocolate bars." They go on to state that their 2 new fat loss compounds (as mentioned above) increases the effectiveness of PEA by about 40 fold. So basically, 40 x 1000 = 40,000. But anyways, that's a moot point.

NorEpiphex α2-Andrenergic Blockade Complex contains 3 types of Yohimbe: 11-Hydroxy Yohimbine, Yohimbine HCL, Alpha-Yohimbine. Yohimbe is a tree that grows in Africa, and the natives there have used the crude bark and purified compound to enhance sexual desire and performance. Yohimbe has been used for centuries as an aphrodisiac. It has even been smoked as a hallucinogen. Nowadays, Yohimbe bark extract is mostly used to treat impotence for men and women. Yohimbe is also commonly used in diet pills and fat burners for weight loss.

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VPX Meltdown Review - Backed By Science

When we write reviews, it's not often that we come across a product that has solid scientific research that's published and peer reviewed to back up its claims. So needless to say, we were quite surprised to find 2 studies performed on VPX Meltdown which were published in the Journal of the International Society of Sports Nutrition, which is a peer reviewed publication. The findings of these 2 studies were also presented at the Fifth International Society of Sports Nutrition (ISSN) Conference and Expo. I'll briefly explain the results of these 2 studies below.

Study 1:

VPX Meltdown significantly increases energy expenditure and fat oxidation without affecting hemodynamic variables in a randomized, double-blind, cross-over clinical research trial
Jean Jitomir, Erika Nassar, Julie Culbertson, Jen Moreillon, Matt Cooke, Thomas Buford, Geoffrey Hudson and Darryn Willoughby

This study evaluated the thermogenic effects of VPX Meltdown, and its effects on energy expenditure, and fat oxidation. The double blind, placebo controlled, cross over study involved 12 healthy male participants aged 18 to 35. They rested for one hour while their energy expenditure, respiratory exchange ratio, heart rate, and blood pressure were measured. The subjects consumed either VPX Meltdown, or a placebo supplement afterwards Following the supplementation, the subjects rested for another hour while the same stats were measured. After the second rest phase, the subjects performed a maximal exercise test on the treadmill, after which, the same measurements were recorded one more time.

The study found that VPX Meltdown significantly increased energy expenditure after exercise and energy expenditure at rest compared to the placebo group. They also found that heart rate and blood pressure where not significantly different between the VPX Meltdown group and the placebo group. The study concludes that "VPX Meltdown enhances energy expenditure and fat oxidation more than placebo for several hours after ingestion in fully rested and post-exercise states without any adverse hemodynamic responses." [2]

Study 2:

Thermogenic effect of an acute ingestion of a weight loss supplement
Jay Hoffman , Jie Kang, Nicholas Ratamess, Stefanie Rashti, Christopher Tranchina, Neil Kelly and Avery Faigenbaum

This study examined the effects of a weight loss supplement (VPX Meltdown) on resting oxygen uptake, respiratory quotient, caloric expenditure, heart rate, and blood pressure in healthy and physically active individuals.

The randomized and double blind study involved 10 healthy subjects (5 male and 5 female) who underwent 2 testing sessions, where the subjects were given either 3 capsules of VPX Meltdown, or 3 capsules of a placebo. The subjects then rested for 3 hours where their oxygen uptake, heart rate, blood pressure, caloric expenditure were measured at different time intervals. This study found that there was a significant increase in energy expenditure in the VPX Meltdown group compared to placebo group. They also noted that there was a greater utilization of stored fat as an energy source in the VPX Meltdown group. They concluded that consuming VPX Meltdown significantly increased energy expenditure and it also appears to increase heart rate and blood press for 3 hours after ingestion. [3]

What do these studies tell us? The scientific evidence behind VPX Meltdown is solid. There's no questioning the legitimacy of the fat burning potential of VPX Meltdown. Both studies had similar results, finding that Meltdown significantly increases energy expenditure, caloric expenditure, and the second study also found it to utilize more stored fat as an energy source. Aside from these scientific studies, there are also plenty of anecdotal evidence, where users are reporting very positive feedback of using VPX Meltdown.

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1. J Lipid Mediat Cell Signal. 1997 Nov;17(2):115-34.
Enhanced hepatic fatty acid oxidation and upregulated carnitine palmitoyltransferase II gene expression by methyl 3-thiaoctadeca-6,9,12,15-tetraenoate in rats.
Willumsen N, Vaagenes H, Rustan AC, Grav H, Lundquist M, Skattebøl L, Songstad J, Berge

2. VPX Meltdown significantly increases energy expenditure and fat oxidation without affecting hemodynamic variables in a randomized, double-blind, cross-over clinical research trial
Jean Jitomir, Erika Nassar, Julie Culbertson, Jen Moreillon, Matt Cooke, Thomas Buford, Geoffrey Hudson and Darryn Willoughby

3. Thermogenic effect of an acute ingestion of a weight loss supplement
Jay Hoffman , Jie Kang, Nicholas Ratamess, Stefanie Rashti, Christopher Tranchina, Neil Kelly and Avery Faigenbaum

Oct 2008