Avant Labs Lipoderm Ultra Ingredients
Yohimbe HCl, caffeine, octopamine HCl, sesamin, synephrine, acetyl-lcarntine, ascorbyl palmitate, and lecithin.
Other Ingredients:
Benzyl alcohol, water isopropyl alcohol, triglyceride complex, n-methyl-2-pyrroidinone, laurocapram, l-menthol and carbomer
The key active ingredients in Lipoderm Ultra are Yohimbe, caffeine, octopamine, sesamin, synephrine, and several others. Below, we'll take a somewhat detailed look at these individual ingredients to gain a better understand of Lipoderm Ultra.
Yohimbine HCL is a key ingredient in Lipoderm Ultra fat loss gel. It is an alkaloid found in the inner bar of a tree grown in south Africa. Yohimbe has been used as an aphrodisiac for centuries, and is now showing some promise in the areas concerning weight loss. Although there are still relatively few studies done on Yohimbe's effects on fat loss, I managed to find several of them. Below is a very promising study demonstrating the positive effects Yohimbine has on body fat composition.
Study: The main aim of this study was to determine the effects of yohimbine supplementation on body composition and exercise performance in professional soccer players. The athletes (20 top-level male soccer players) were allocated to two randomly assigned trials.
Subjects in the yohimbine group orally ingested tablets that contains yohimbine at a dose of 20 milligrams per day in two equal doses for 21 days. Subjects in the placebo group ingested an equal number of identical-looking pills that contained cellulose.
There were no statistically significant changes in body mass and muscle mass within or between trials (p > 0.05) after the supplementation protocol. Percentage of body fat significantly decreased in the yohimbine group after the supplementation protocol (9.3 +/- 1.1 vs. 7.1 +/- 2.2%; p < 0.05).
Furthermore, fat mass was significantly lower in the yohimbine versus placebo trial at post supplementation assessment (7.1 +/- 2.2 vs. 9.2 +/- 1.9%; p < 0.05). There were no changes in exercise performance indicators (bench and leg press, vertical jump, dribble and power test results, shuttle run) within or between. trials (p > 0.05).
No subject reported any side effects from yohimbine. The results of the current study indicate that supplementation with yohimbine combined with resistance training does not significantly alter the body mass, muscle mass, or performance indicators in professional soccer players. Nonetheless, yohimbine supplementation appears to be suitable as a fat loss strategy in elite athletes.
Ostojic SM. Institute of Sports Medicine, Sports Academy, Belgrade, Serbia and Montenegro. sergej@panet.co.yu
To sum up the above findings, the researchers found that while Yohimbine had no effects of exercise performance or body mass changes, it helped reduce the body fat mass in subjects that took the Yohimbine supplement, leading to the conclusion that taking Yohimbine supplement is an effective way to lose body fat.
Sesamin is one of the most abundant lignans in sesame seeds. Various studies have shown that sesamin helps reduce fat and improve health. Below are 2 illustrative studies done on Sesamin:
Sesamin, a sesame lignan, is a potent inducer of hepatic fatty acid oxidation in the rat.
Ashakumary L, Rouyer I, Takahashi Y, Ide T, Fukuda N, Aoyama T, Hashimoto T, Mizugaki M, Sugano M.
Laboratory of Nutrition Biochemistry, National Food Research Institute, Ministry of Agriculture, Forestry and Fisheries, Tsukuba, Japan.
The study examined the effects of sesamin on hepatic fatty acid oxidation in rats that were fed various amounts of sesamin for 15 days - separated into 4 groups fed with 0%, 0.1%, 0.2%, 0.3%, and 0.4%. Mitochondrial activity almost doubled in rats on the 0.5% sesamin diet. Peroxisomal activity increased more than 10-fold in rats fed a 0.5% sesamin diet in relation to rats on the sesamin-free diet. They found that dietary sesamin greatly increased the hepatic activity of fatty acid oxidation enzymes, leading to the conclusion that "an alteration in hepatic fatty acid metabolism may therefore account for the serum lipid-lowering effect of sesamin in the rat".
Metabolism. 1999 Oct;48(10):1303-13.
Sesamin, a sesame lignan, as a potent serum lipid-lowering food component.
Personal Authors: Ide, T., Kushiro, M., Takahashi, Y., Shinohara, K., Fukuda, N., Sirato-Yasumoto, S.
Author Affiliation: Division of Food Functionality, National Food Research Institute, Tsukuba, Ibaraki 305-8642, Japan.
This research examined the effect of sesamin on the hepatic fatty acid metabolism in the rat. The rats were fed different levels of sesamin, and the researchers found that rats fed the highest levels of 0.5% sesamin in their diet had double the mitochondrial activity, and 10 times high perioxisomal activity. The study concluded that sesamin affects the fatty acid metabolism and lipoprotein production in the liver, and hence lowers the serum lipid levels
Document Title: JARQ, Japan Agricultural Research Quarterly, 2003 (Vol. 37) (No. 3) 151-158
I was unable to find any studies of sesamin performed with human subjects - all the studies available were performed on rats. However, these studies do speak well for the sesamin and its benefits for fat loss. Sesamin is also gaining more recognition and popularity in various supplements and fat burners.
Synephrine is promoted as a fat loss supplement; however, its effectiveness is widely debated. Synephrine is derived from the fruit of citrus aurantium, which is also known as Bitter Orange, which has been used in Chinese
medicine to treat chest congestion. It is a popular ingredient in many weight loss products and diet pills. Currently, there are conflicting evidence and views on the effectiveness of bitter orange - below we present 2 studies which illustrate the conflicting views.
Seville orange (Citrus aurantium)
Fugh-Berman A, Myers A.
Department of Physiology & Biophysics, Georgetown University, Box 571460, Washington, District of Columbia 20057-1460, USA. fughberman@aol.com
Seville orange (Citrus aurantium) extracts are being marketed as a safe alternative to ephedra in herbal weight-loss products, but C. aurantium may also have the potential to cause adverse health effects. C. aurantium contains synephrine (oxedrine), which is structurally similar to epinephrine. Although no adverse events have been associated with ingestion of C. aurantium products thus far, synephrine increases blood pressure in humans and other species, and has the potential to increase cardiovascular events.
Additionally, C. aurantium contains 6',7'-dihydroxybergamottin and bergapten, both of which inhibit cytochrome P450-3A, and would be expected to increase serum levels of many drugs. There is little evidence that products containing C. aurantium are an effective aid to weight loss. Synephrine has lipolytic effects in human fat cells only at high doses, and octopamine does not have lipolytic effects in human adipocytes.
Exp Biol Med (Maywood). 2004 Sep;229(8):698-704.
Citrus aurantium and synephrine alkaloids in the treatment of overweight and obesity: an update.
Haaz S, Fontaine KR, Cutter G, Limdi N, Perumean-Chaney S, Allison DB.
Division of Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Obesity is a major health problem facing the developed and developing world. Efforts by individuals, health professionals, educators, and policy makers to combat the escalating trend of growing obesity prevalence have been multifaceted and mixed in outcome. Various dietary supplements have been marketed to reduce obesity. These products have been suggested to accomplish this by decreasing energy intake and energy absorption, and/or increasing metabolic rate.
Citrus aurantium, which contains several compounds including synephrine alkaloids, has been suggested as a safe alternative to ephedra. This review examines the evidence for safety and efficacy of C. aurantium and synephrine alkaloids as examined in animal studies, clinical weight loss trials, acute physiologic studies and case reports.
The study concludes that while some evidence is promising, larger and more rigorous clinical trials are necessary to draw adequate conclusions regarding the safety and efficacy of C. aurantium and synephrine alkaloids for promoting weight loss.
Obes Rev. 2006 Feb;7(1):79-88.
As you can see from the two above studies, first study finds no conclusive evidence to support the claim that citrus aurantium is an effective weight loss aid, while the second study concludes that there are some promising evidence, but more clinical trials are needed to examine the safety and efficacy of Citrus Aurantium.
When all's said and done, what matters most is how will Lipoderm work for real, live human beings. There are many positive user feedbacks on Lipoderm reporting good results. I can say that I've had somewhat decent results from using Lipoderm. I'm not a big guy, nor do I have a high amount of body fat (about 10%), so I used Lipoderm Ultra exclusively on my waist area to bring out the extra definition for the mid section. There are some users reporting leaking problems with their bottle, but I did not experience anything of this sort - maybe I was just lucky, or they were unlucky? =)
Anyway, if you are quite lean overall, but have some stubborn fat around the waist area, you may find Lipoderm Ultra to come in handy getting rid of those last little bit of stubborn fat.
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